Originally Posted by uberintj
open the hood and #5 plug wire boot is ON FIRE. Again, brand new plugs and wires - mid-grade.

your truck probably has 4.11 or 4.56 gears.I have 4.11s in my F350,not too bad out on the road..my Chevy K30 has 4.56 gears, maxed out will do 60 on the highway,but it will pull a house down.
go with some 7mm MSD wires, they will set you back some $80 or so from Summit Racing..best wire set Ive ever used..anyway all said, have you checked the fuel pump pressure?
maybe your in-tank pump is failing and not giving the EFI the pressure it needs